@Erwin, you really should install all your games in a "Games" folder outside of 'Program Files (x86)' location. Somewhere, someone told me those wise words. Might be why you are having issues with your game, may be worth a shot.
Also, installing to a folder on your Desktop is a good way to test run troublesome issues (especially true for older programs /games). If the Desktop install works, you could always move that folder to a better location ("Games" folder), just re-map the quick start icon (that should work).