Wiki says:
"Despite the weight, recoil is significant, and shooters must be sure to choose components (i.e., scopes and bipods) that can handle the abuse. The sheer size and weight of these weapons makes them impractical for hunting use, as they cannot be carried afield. Thus, they are largely "range queens"—rifles that are brought to the range for a fun time, but not usually used for hunting or other "more practical" uses....
...In a 110 lb (50 kg) rifle, this will develop well over 200 ft·lbf (270 J) of free recoil energy if an efficient muzzle brake is not used. This is far beyond the shoulder-firing capacity of nearly all humans, even without considering the difficulty of shouldering such a heavy rifle. Shooting is usually heavy "lead sled" or similar shooting rest, and the rifle is not held to the shoulder because of the severe recoil and possible injury. The rifle scope has significant eye relief to avoid injuring the ocular orbit."